Free fatty acid receptor
The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. [2]
| free fatty acid receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FFAR1, FFA1R | ||||||
| Alt. symbols | GPR40 | ||||||
| NCBI gene | 2864 | ||||||
| HGNC | 4498 | ||||||
| OMIM | 603820 | ||||||
| RefSeq | NM_005303 | ||||||
| UniProt | O14842 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.1 | ||||||
| |||||||
| free fatty acid receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FFAR2 | ||||||
| Alt. symbols | GPR43, FFA2R | ||||||
| NCBI gene | 2867 | ||||||
| HGNC | 4501 | ||||||
| OMIM | 603823 | ||||||
| RefSeq | NM_005306 | ||||||
| UniProt | O15552 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.1 | ||||||
| |||||||
| free fatty acid receptor 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FFAR3 | ||||||
| Alt. symbols | GPR41, FFA3R | ||||||
| NCBI gene | 2865 | ||||||
| HGNC | 4499 | ||||||
| OMIM | 603821 | ||||||
| RefSeq | NM_005304 | ||||||
| UniProt | O14843 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.1 | ||||||
| |||||||
| G protein-coupled receptor 42 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GPR42 | ||||||
| Alt. symbols | GPR41L, FFAR1L | ||||||
| NCBI gene | 2866 | ||||||
| HGNC | 4500 | ||||||
| OMIM | 603822 | ||||||
| RefSeq | NM_005305 | ||||||
| UniProt | O15529 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q31.1 | ||||||
| |||||||
References
- Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
- Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32 (1): –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.
External links
- "Free Fatty Acid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- FFAR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- G-protein+coupled+receptor+43,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FFAR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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