CELSR3

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.[4][5]

CELSR3
Identifiers
AliasesCELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDsOMIM: 604264 MGI: 1858236 HomoloGene: 1077 GeneCards: CELSR3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.31Start48,636,463 bp[1]
End48,662,886 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1951

107934

Ensembl

ENSG00000008300

ENSMUSG00000023473

UniProt

Q9NYQ7

Q91ZI0

RefSeq (mRNA)

NM_001407

NM_080437

RefSeq (protein)

NP_001398

NP_536685
NP_001346501
NP_001346502

Location (UCSC)Chr 3: 48.64 – 48.66 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000008300 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
  5. "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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