GPR101

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[5][6]

GPR101
Identifiers
AliasesGPR101, GPCR6, PAGH2, G protein-coupled receptor 101, PITA2
External IDsOMIM: 300393 MGI: 2685211 HomoloGene: 14273 GeneCards: GPR101
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq26.3Start137,027,447 bp[1]
End137,033,847 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

83550

245424

Ensembl

ENSG00000165370

ENSMUSG00000036357

UniProt

Q96P66

Q80T62

RefSeq (mRNA)

NM_054021

NM_001033360

RefSeq (protein)

NP_473362

NP_001028532

Location (UCSC)Chr X: 137.03 – 137.03 MbChr X: 57.5 – 57.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[6]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[7]

References
  1. GRCh38: Ensembl release 89: ENSG00000165370 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036357 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  6. "Entrez Gene: GPR101 G protein-coupled receptor 101".
  7. Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371 (25): 2363–74. doi:10.1056/NEJMoa1408028. PMC 4291174. PMID 25470569.

Further reading


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