Estriol dipropionate

Estriol dipropionate, or estriol 3,17β-dipropionate, is a synthetic estrogen and estrogen ester – specifically, the C3 and C17β dipropionate ester of estriol – which was first described in 1963 and was never marketed.[1][2][3] Following a single intramuscular injection of 6.94 mg estriol dipropionate (equivalent to 5.0 mg estriol) in an oil solution, peak levels of estriol occurred after 0.83 days, an elimination half-life of 12.7 hours was observed, and estriol levels remained elevated for up to 4 days.[1][3] For comparison, the duration of estriol was much shorter, while that of estriol dihexanoate was much longer.[1][3]

Estriol dipropionate
Clinical data
Other namesOestriol dipropionate; Estriol 3,17β-dipropionate; 16α-Hydroxyestra-1,3,5(10)-triene-3,17β-diyl dipropanoate
Routes of
administration
Intramuscular injection
Drug classEstrogen; Estrogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC24H32O5
Molar mass400.515 g·mol−1
3D model (JSmol)

See also

References

  1. Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 273–. ISBN 978-3-642-60107-1.
  2. Tsuneda K, Yamada J, Yasuda K, Mori H (April 1963). "Preparation of some estriol esters". Chem. Pharm. Bull. 11: 510–4. doi:10.1248/cpb.11.510. PMID 13994597.
  3. Heithecker R, Aedo AR, Landgren BM, Cekan SZ (1991). "Plasma estriol levels after intramuscular injection of estriol and two of its esters". Horm. Res. 35 (6): 234–8. doi:10.1159/000181911. PMID 1819548.


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