Methylpiperidinopyrazole

Methylpiperidinopyrazole (MPP) is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor.[1][2] It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.[3]

Methylpiperidinopyrazole
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC29H31N3O3
Molar mass469.585 g·mol−1
3D model (JSmol)

See also

References
  1. Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, Katzenellenbogen BS (March 2002). "Antagonists selective for estrogen receptor alpha". Endocrinology. 143 (3): 941–7. doi:10.1210/endo.143.3.8704. PMID 11861516.
  2. Zhou HB, Carlson KE, Stossi F, Katzenellenbogen BS, Katzenellenbogen JA (January 2009). "Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity". Bioorganic & Medicinal Chemistry Letters. 19 (1): 108–10. doi:10.1016/j.bmcl.2008.11.006. PMC 2711511. PMID 19014882.
  3. Ottow E, Weinmann H (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 50–. ISBN 978-3-527-62330-3.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.