11β-Methoxyestradiol
11β-Methoxyestradiol (11β-MeOE2; developmental code name RU-2504) is a synthetic steroidal estrogen which was never marketed.[1][2][3] It has about 86% of the relative binding affinity of estradiol for the estrogen receptor.[1][2] 11β-MeOE2 is structurally related to moxestrol (11β-methoxy-17α-ethynylestradiol).[3][2] 11β-MeOE2 and moxestrol are substantially more potent than their non-methoxylated analogues (estradiol and ethinylestradiol, respectively) in mice.[3]
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| Other names | 11β-MeOE2; 11βOMeEST; RU-2504; 11β-Methoxyestra-1,3,5(10)-triene-3,17β-diol |
| Drug class | Estrogen |
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| Formula | C19H26O3 |
| Molar mass | 302.414 g·mol−1 |
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See also
References
- Wolohan P, Reichert DE (March 2007). "CoMSIA and docking study of rhenium based estrogen receptor ligand analogs". Steroids. 72 (3): 247–60. doi:10.1016/j.steroids.2006.11.011. PMC 1964785. PMID 17280694.
- Katzenellenbogen, J. A.; Muthyala, R. (2003). "Interactions of exogenous endocrine active substances with nuclear receptors". Pure and Applied Chemistry. 75 (11–12): 1797–1817. doi:10.1351/pac200375111797. ISSN 1365-3075. S2CID 86680540.
- Azadian-Boulanger G, Bertin D (1973). "Synthèse et activité utérotrophique des 11β-méthoxy estradiol 11β-méthoxy estriol et 11β-méthoxy 17α-éthynyl estradiol" [Synthesis and uterotropic activity of 11β-methoxyestradiol, 11β-methoxyestriol, and 11β-methoxy-17α-ethynylestradiol]. Chimica Therapeutica. 8 (4): 451–454. ISSN 0009-4374.
The prepn. and estrogenic activity of the 11β-methoxylated derivs. of estradiol, estriol, and 17α-ethynylestradiol were described. When administered orally to mice, the 3 compds. were from 10 to 1000 times more active than the corresponding nonmethoxylated estrogens.
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