LGR4

LGR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4
External IDs	OMIM: 606666 MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	27,472,790 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	110,014,257 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• signal transducer activity; • GO:0001948 protein binding; • transmembrane signaling receptor activity; • G-protein coupled receptor activity; • protein-hormone receptor activity; • G-protein coupled peptide receptor activity;
Cellular component	• integral component of membrane; • membrane; • integral component of plasma membrane; • cell membrane;
Biological process	• hair follicle development; • G-protein coupled receptor signaling pathway; • cell differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • male genitalia development; • metanephric nephron tubule morphogenesis; • rhythmic process; • metanephric glomerulus development; • immune system process; • epithelial cell proliferation; • Wnt signaling pathway; • tube morphogenesis; • positive regulation of transcription, DNA-templated; • multicellular organism development; • cell differentiation involved in metanephros development; • intestinal stem cell homeostasis; • epithelial cell proliferation involved in renal tubule morphogenesis; • circadian rhythm; • canonical Wnt signaling pathway involved in metanephric kidney development; • digestive tract development; • innate immune system; • negative regulation of transcription, DNA-templated; • signal transduction; • positive regulation of canonical Wnt signaling pathway; • bone remodeling; • circadian regulation of gene expression; • spermatogenesis; • negative regulation of cytokine secretion; • osteoblast differentiation; • bone mineralization; • negative regulation of toll-like receptor signaling pathway; • adenylate cyclase-activating G-protein coupled receptor signaling pathway; • activation of adenylate cyclase activity; • hormone-mediated signaling pathway; • negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55366
	107515
	ENSG00000205213
	ENSMUSG00000050199
	Q9BXB1
	A2ARI4
	NM_018490; NM_001346432
	NM_172671
	NP_001333361; NP_060960
	NP_766259
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[5][6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.
"Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10894923-5] Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.

[entrez-6] "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

LGR4

References

Further reading