Binospirone
Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.[1] It has anxiolytic effects.[2]
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| Formula | C20H26N2O4 |
| Molar mass | 358.438 g·mol−1 |
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Synthesis
Binospirone synthesis: EP0236930
See also
References
- Bertrand F, Lehmann O, Galani R, Lazarus C, Jeltsch H, Cassel JC (April 2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology, Biochemistry, and Behavior. 68 (4): 647–60. doi:10.1016/S0091-3057(01)00448-8. PMID 11526961. S2CID 8595441.
- Moser PC, Tricklebank MD, Middlemiss DN, Mir AK, Hibert MF, Fozard JR (February 1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology. 99 (2): 343–9. doi:10.1111/j.1476-5381.1990.tb14706.x. PMC 1917389. PMID 1970269.
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