Aryl hydrocarbon receptor nuclear translocator

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

ARNT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
Identifiers
Aliases	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator
External IDs	OMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 150,809,713 bp[1] End 150,876,708 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 40.74 cM Start 95,434,388 bp[2] End 95,497,240 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • aryl hydrocarbon receptor binding • transcription factor binding • GO:0001948 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein homodimerization activity • sequence-specific double-stranded DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity Cellular component • cytoplasm • transcription regulator complex • nucleoplasm • RNA polymerase II transcription factor complex • cell nucleus • nuclear body Biological process • positive regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • response to hypoxia • regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • positive regulation of erythrocyte differentiation • embryonic placenta development • mRNA transcription from RNA polymerase II promoter • positive regulation of protein sumoylation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of vascular endothelial growth factor production • positive regulation of glycolytic process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of hormone biosynthetic process • xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	405	11863
Ensembl	ENSG00000143437	ENSMUSG00000015522
UniProt	P27540	P53762
RefSeq (mRNA)	NM_001197325 NM_001286035 NM_001286036 NM_001668 NM_178426 NM_178427 NM_001350224 NM_001350225 NM_001350226	NM_001037737 NM_009709
RefSeq (protein)	NP_001184254 NP_001272964 NP_001272965 NP_001659 NP_848514 NP_001337153 NP_001337154 NP_001337155	NP_001032826 NP_033839
Location (UCSC)	Chr 1: 150.81 – 150.88 Mb	Chr 3: 95.43 – 95.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only into[5] the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.