FOXH1

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[5][6]

FOXH1
Identifiers
AliasesFOXH1, FAST-1, FAST1, forkhead box H1
External IDsOMIM: 603621 MGI: 1347465 HomoloGene: 2914 GeneCards: FOXH1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start144,473,412 bp[1]
End144,475,849 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8928

14106

Ensembl

ENSG00000160973

ENSMUSG00000033837

UniProt

O75593

O88621

RefSeq (mRNA)

NM_003923

NM_007989

RefSeq (protein)

NP_003914

NP_032015

Location (UCSC)Chr 8: 144.47 – 144.48 MbChr 15: 76.67 – 76.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[6]

Interactions

FOXH1 has been shown to interact with DRAP1[7] and Mothers against decapentaplegic homolog 2.[8][9][10][11][12]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000160973 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033837 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
  6. "Entrez Gene: FOXH1 forkhead box H1".
  7. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. S2CID 22923124.
  8. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. S2CID 6907878.
  9. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. doi:10.1128/MCB.19.1.424. PMC 83900. PMID 9858566.
  10. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
  11. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
  12. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972. S2CID 11927346.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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