Liver receptor homolog-1

NR5A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RWV, 1YOK, 1YUC, 1ZDU, 2A66, 3PLZ, 3TX7, 4DOR, 4DOS, 4IS8, 4ONI, 4PLD, 4PLE
Identifiers
Aliases	NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2, nuclear receptor subfamily 5 group A member 2
External IDs	OMIM: 604453 MGI: 1346834 HomoloGene: 20827 GeneCards: NR5A2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	200,177,420 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	136,960,448 bp[2]
Gene ontology
Molecular function	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • transcription regulatory region sequence-specific DNA binding; • metal ion binding; • steroid hormone receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • GO:0001948 protein binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • double-stranded DNA binding; • phospholipid binding; • lipid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cytoplasm; • nucleoplasm; • RNA polymerase II transcription factor complex; • cell nucleus;
Biological process	• regulation of transcription, DNA-templated; • epithelial cell differentiation; • pancreas morphogenesis; • bile acid metabolic process; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • regulation of cell proliferation; • histogenesis; • hormone-mediated signaling pathway; • cholesterol homeostasis; • positive regulation of viral genome replication; • transcription initiation from RNA polymerase II promoter; • steroid hormone mediated signaling pathway; • positive regulation of transcription from RNA polymerase II promoter; • homeostatic process; • calcineurin-mediated signaling; • cellular response to leukemia inhibitory factor; • embryo development ending in birth or egg hatching;
	Sources:Amigo / QuickGO
Orthologs
	2494
	26424
	ENSG00000116833
	ENSMUSG00000026398
	O00482
	P45448
	NM_001276464; NM_003822; NM_205860
	NM_001159769; NM_030676
	NP_001263393; NP_003813; NP_995582
	NP_001153241; NP_109601
	Wikidata
View/Edit Human	View/Edit Mouse

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[5][6] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[7][8][9]

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.[10]

Interactions

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[11][12]

References

GRCh38: Ensembl release 89: ENSG00000116833 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026398 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bernier D, Thomassin H, Allard D, Guertin M, Hamel D, Blaquière M, Beauchemin M, LaRue H, Estable-Puig M, Bélanger L (Mar 1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology. 13 (3): 1619–33. doi:10.1128/mcb.13.3.1619. PMC 359474. PMID 7680097.
Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. S2CID 46813832.
Fayard E, Auwerx J, Schoonjans K (May 2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
Luo Y, Liang CP, Tall AR (Jul 2001). "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry. 276 (27): 24767–73. doi:10.1074/jbc.M100912200. PMID 11331284.
Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.
Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology. 25 (9): 3492–505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.
Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

External links

NR5A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116833 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026398 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7680097-5] Bernier D, Thomassin H, Allard D, Guertin M, Hamel D, Blaquière M, Beauchemin M, LaRue H, Estable-Puig M, Bélanger L (Mar 1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology. 13 (3): 1619–33. doi:10.1128/mcb.13.3.1619. PMC 359474. PMID 7680097.

[pmid9858833-6] Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. S2CID 46813832.

[pmid15130581-7] Fayard E, Auwerx J, Schoonjans K (May 2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.

[CETP-8] Luo Y, Liang CP, Tall AR (Jul 2001). "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry. 276 (27): 24767–73. doi:10.1074/jbc.M100912200. PMID 11331284.

[cholesterolhydroxylase-9] Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.

[10] Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology. 25 (9): 3492–505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.

[pmid12198243-11] Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.

[pmid11668176-12] Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

Liver receptor homolog-1

Interactions

References

Further reading

External links