NKX6-2

NKX6-2
Identifiers
Aliases	NKX6-2, GTX, NKX6.2, NKX6B, NK6 homeobox 2, SPAX8
External IDs	OMIM: 605955 MGI: 1352738 HomoloGene: 18580 GeneCards: NKX6-2
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	132,786,147 bp[1]
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus;
Biological process	• multicellular organism development; • positive regulation of glial cell differentiation; • cell differentiation; • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; • oligodendrocyte differentiation; • negative regulation of glial cell differentiation; • regulation of transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of cell fate commitment; • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; • neuromuscular process controlling balance; • positive regulation of cell fate commitment; • central nervous system myelination; • endocrine pancreas development; • regulation of myelination; • negative regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	84504
	14912
	ENSG00000148826
	ENSMUSG00000041309
	Q9C056
	D3Z4R4
	NM_177400
	NM_183248
	NP_796374
	NP_899071
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.[4][5]

References

GRCh38: Ensembl release 89: ENSG00000148826 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lee SH, Davison JA, Vidal SM, Belouchi A (February 2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
"Entrez Gene: NK6 homeobox 2".

NKX6-2

References

Further reading