Neuron-derived orphan receptor 1

NR4A3
Identifiers
Aliases	NR4A3, CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3
External IDs	OMIM: 600542 MGI: 1352457 HomoloGene: 5074 GeneCards: NR4A3
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	99,866,891 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	48,086,447 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • protein homodimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • steroid hormone receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • core promoter sequence-specific DNA binding; • GO:0001948 protein binding; • histone acetyltransferase binding; • glucocorticoid receptor binding; • transcription coactivator binding; • protein kinase binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • cAMP response element binding; • RNA polymerase II regulatory region sequence-specific DNA binding;
Cellular component	• transcription regulator complex; • mast cell granule; • nucleoplasm; • cell nucleus;
Biological process	• negative regulation of neuron apoptotic process; • cellular response to catecholamine stimulus; • semicircular canal morphogenesis; • regulation of transcription, DNA-templated; • neuromuscular process controlling balance; • positive regulation of epithelial cell proliferation; • common myeloid progenitor cell proliferation; • pyruvate oxidation; • negative regulation of oxidative stress-induced neuron death; • mesoderm formation; • response to peptide hormone; • negative regulation of apoptotic process; • positive regulation of leukocyte apoptotic process; • negative regulation of transcription from RNA polymerase II promoter; • regulation of smooth muscle cell proliferation; • cellular response to leptin stimulus; • transcription, DNA-templated; • positive regulation of cardiac muscle hypertrophy; • axon guidance; • positive regulation of transcription, DNA-templated; • adult behavior; • positive regulation of cell cycle; • negative regulation of hydrogen peroxide-induced neuron death; • gastrulation; • positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway; • animal organ regeneration; • inner ear morphogenesis; • positive regulation of mast cell cytokine production; • cellular respiration; • vestibular reflex; • energy homeostasis; • cellular response to corticotropin-releasing hormone stimulus; • mast cell degranulation; • transcription initiation from RNA polymerase II promoter; • positive regulation of feeding behavior; • positive regulation of glucose transport; • hippocampus development; • positive regulation of monocyte aggregation; • fat cell differentiation; • response to hydrogen peroxide; • regulation of type B pancreatic cell proliferation; • positive regulation of transcription from RNA polymerase II promoter; • steroid hormone mediated signaling pathway; • positive regulation of smooth muscle cell proliferation; • positive regulation of fatty acid oxidation; • intracellular receptor signaling pathway; • regulation of megakaryocyte differentiation; • platelet-derived growth factor receptor signaling pathway; • positive regulation of vascular smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8013
	18124
	ENSG00000119508
	ENSMUSG00000028341
	Q92570
	Q9QZB6
	NM_006981; NM_173198; NM_173199; NM_173200
	NM_015743; NM_001307989
	NP_008912; NP_775291; NP_775292
	NP_001294918; NP_056558
	Wikidata
View/Edit Human	View/Edit Mouse

The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.[5] NOR1 is a member of the nuclear receptor family of intracellular transcription factors.

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism[6][7] and apoptosis[8]

Interactions

Neuron-derived orphan receptor 1 has been shown to interact with SIX3.[9][10]

References

GRCh38: Ensembl release 89: ENSG00000119508 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028341 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hedvat CV, Irving SG (Dec 1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Molecular Endocrinology. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405.
Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (Nov 2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (Jun 2008). "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.
Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (Nov 2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". The Journal of Biological Chemistry. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922.
Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (Jan 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Research. 63 (2): 449–54. PMID 12543801.
Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Developmental Neuroscience. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923. S2CID 84167063.

External links

NR4A3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119508 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028341 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8614405-5] Hedvat CV, Irving SG (Dec 1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Molecular Endocrinology. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405.

[pmid16901967-6] Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (Nov 2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.

[pmid18325999-7] Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (Jun 2008). "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.

[pmid16945922-8] Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (Nov 2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". The Journal of Biological Chemistry. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922.

[pmid12543801-9] Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (Jan 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Research. 63 (2): 449–54. PMID 12543801.

[pmid11173923-10] Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Developmental Neuroscience. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923. S2CID 84167063.

Neuron-derived orphan receptor 1

Interactions

See also

References

Further reading

External links