SOX5

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[5][6]

SOX5
Identifiers
AliasesSOX5, L-L-SOX5B, L-SOX5F, LAMSHF, SRY-box 5, SRY-box transcription factor 5
External IDsOMIM: 604975 MGI: 98367 HomoloGene: 21378 GeneCards: SOX5
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p12.1Start23,529,504 bp[1]
End24,562,544 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6660

20678

Ensembl

ENSG00000134532

ENSMUSG00000041540

UniProt

P35711

P35710

RefSeq (mRNA)

NM_001113559
NM_001243163
NM_011444
NM_001347506

RefSeq (protein)

NP_001107031
NP_001230092
NP_001334435
NP_035574

Location (UCSC)Chr 12: 23.53 – 24.56 MbChr 6: 143.83 – 144.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000134532 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041540 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Sep 1996). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics. 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465.
  6. "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.