MYT1

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[5][6][7]

MYT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDsOMIM: 600379 MGI: 1100535 HomoloGene: 3332 GeneCards: MYT1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.33Start64,102,394 bp[1]
End64,242,253 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4661

17932

Ensembl

ENSG00000196132
ENSG00000276876

ENSMUSG00000010505

UniProt

Q01538

Q8CFC2

RefSeq (mRNA)

NM_004535

NM_001171615
NM_001171616
NM_001171680
NM_008665

RefSeq (protein)

NP_004526

NP_001165086
NP_001165087
NP_001165151
NP_032691

Location (UCSC)Chr 20: 64.1 – 64.24 MbChr 2: 181.76 – 181.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[7]

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles. [§ 1]

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MECP2 and associated Rett Syndrome edit
  1. The interactive pathway map can be edited at WikiPathways: "WP3584".

Interactions

MYT1 has been shown to interact with PIN1.[8]

References

  1. ENSG00000276876 GRCh38: Ensembl release 89: ENSG00000196132, ENSG00000276876 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000010505 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
  6. Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
  7. "Entrez Gene: MYT1 myelin transcription factor 1".
  8. Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. PMID 10504341.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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