MYC

MYC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A93, 1EE4, 1MV0, 1NKP, 2A93, 2OR9, 4Y7R
Identifiers
Aliases	MYC, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc
External IDs	OMIM: 190080 MGI: 97250 HomoloGene: 31092 GeneCards: MYC
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	127,742,951 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	61,990,374 bp[2]
Gene ontology
Molecular function	• DNA binding; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • E-box binding; • GO:0001948 protein binding; • repressing transcription factor binding; • activating transcription factor binding; • GO:0032403 macromolecular complex binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	• nucleoplasm; • nucleolus; • cell nucleus; • nuclear chromatin; • macromolecular complex;
Biological process	• Notch signaling pathway; • chromatin remodeling; • negative regulation of monocyte differentiation; • positive regulation of metanephric cap mesenchymal cell proliferation; • regulation of transcription, DNA-templated; • regulation of telomere maintenance; • positive regulation of epithelial cell proliferation; • positive regulation of fibroblast proliferation; • cellular response to UV; • oxygen transport; • negative regulation of apoptotic process; • negative regulation of transcription from RNA polymerase II promoter; • chromosome organization; • MAPK cascade; • cellular response to DNA damage stimulus; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • branching involved in ureteric bud morphogenesis; • cellular response to drug; • negative regulation of cell division; • fibroblast apoptotic process; • positive regulation of mesenchymal cell proliferation; • cell cycle arrest; • positive regulation of response to DNA damage stimulus; • positive regulation of cell proliferation; • positive regulation of DNA biosynthetic process; • regulation of gene expression; • canonical Wnt signaling pathway; • negative regulation of stress-activated MAPK cascade; • energy reserve metabolic process; • response to growth factor; • response to gamma radiation; • negative regulation of fibroblast proliferation; • response to drug; • positive regulation of transcription from RNA polymerase II promoter; • cellular iron ion homeostasis; • beta-catenin-TCF complex assembly; • transcription, DNA-templated; • transcription from RNA polymerase II promoter; • regulation of transcription from RNA polymerase II promoter; • protein deubiquitination; • positive regulation of transcription, DNA-templated; • positive regulation of telomerase activity; • positive regulation of gene expression; • protein-DNA complex disassembly; • ERK1 and ERK2 cascade; • cellular response to hypoxia; • G1/S transition of mitotic cell cycle; • cytokine-mediated signaling pathway; • positive regulation of DNA methylation;
	Sources:Amigo / QuickGO
Orthologs
	4609
	17869
	ENSG00000136997
	ENSMUSG00000022346
	P01106
	P01108
	NM_002467; NM_001354870
	NM_001177352; NM_001177353; NM_001177354; NM_010849
	NP_002458; NP_001341799
	NP_001170823; NP_001170824; NP_001170825; NP_034979
	Wikidata
View/Edit Human	View/Edit Mouse

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene[5] which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.

Function

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].

References

GRCh38: Ensembl release 89: ENSG00000136997 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MYC proto-oncogene, bHLH transcription factor". Retrieved 2020-03-02.

Hann SR, King MW, Bentley DL, Anderson CW, Eisenman RN (January 1988). "A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas". Cell. 52 (2): 185–95. doi:10.1016/0092-8674(88)90507-7. PMID 3277717. S2CID 3012009.
Hiyama T, Haruma K, Kitadai Y, Ito M, Masuda H, Miyamoto M, Tanaka S, Yoshihara M, Sumii K, Shimamoto F, Chayama K (2001). "c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma". Oncol. Rep. 8 (2): 289–92. doi:10.3892/or.8.2.289. PMID 11182042.
Ruf IK, Rhyne PW, Yang H, Borza CM, Hutt-Fletcher LM, Cleveland JL, Sample JT (2001). "EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology and Immunology. 258: 153–60. doi:10.1007/978-3-642-56515-1_10. ISBN 978-3-642-62568-8. PMID 11443860.
Hu HM, Arcinas M, Boxer LM (March 2002). "A Myc-associated zinc finger protein-related factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in Burkitt's lymphoma". J. Biol. Chem. 277 (12): 9819–24. doi:10.1074/jbc.M111426200. PMID 11777933.
Hilker M, Tellmann G, Buerke M, Moersig W, Oelert H, Lehr HA, Hake U (2001). "Expression of the proto-oncogene c-myc in human stenotic aortocoronary bypass grafts". Pathol. Res. Pract. 197 (12): 811–6. doi:10.1078/0344-0338-00164. PMID 11795828.
Feng XH, Liang YY, Liang M, Zhai W, Lin X (January 2002). "Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Mol. Cell. 9 (1): 133–43. doi:10.1016/s1097-2765(01)00430-0. PMID 11804592.
Geick A, Redecker P, Ehrhardt A, Klocke R, Paul D, Halter R (December 2001). "Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells". Transgenic Res. 10 (6): 501–11. doi:10.1023/a:1013085228119. PMID 11817538. S2CID 2305422.
Kuschak TI, Kuschak BC, Taylor CL, Wright JA, Wiener F, Mai S (January 2002). "c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene". Oncogene. 21 (6): 909–20. doi:10.1038/sj.onc.1205145. PMID 11840336.
Chettab K, Zibara K, Belaiba SR, McGregor JL (January 2002). "Acute hyperglycaemia induces changes in the transcription levels of 4 major genes in human endothelial cells: macroarrays-based expression analysis". Thromb. Haemost. 87 (1): 141–8. doi:10.1055/s-0037-1612957. PMID 11848444.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136997 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MYC proto-oncogene, bHLH transcription factor". Retrieved 2020-03-02.

MYC

Function

References

Further reading