KLF8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[6]

KLF8
Identifiers
AliasesKLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDsOMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp11.21Start56,232,356 bp[1]
End56,291,531 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11279

245671

Ensembl

ENSG00000102349

ENSMUSG00000041649

UniProt

O95600

Q8BLM0

RefSeq (mRNA)

NM_173780
NM_001357183

RefSeq (protein)

NP_776141
NP_001344112

Location (UCSC)Chr X: 56.23 – 56.29 MbChr X: 153.24 – 153.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

KLF8 has been shown to interact with CTBP2.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KLF8 Kruppel-like factor 8".
  6. Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Retrieved 12 January 2019.
  7. van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

Further reading


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