FOXK2

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.[5][6]

FOXK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
External IDsOMIM: 147685 MGI: 1916087 HomoloGene: 18748 GeneCards: FOXK2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start82,519,713 bp[1]
End82,644,662 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3607

68837

Ensembl

ENSG00000141568

ENSMUSG00000039275

UniProt

Q01167

Q3UCQ1

RefSeq (mRNA)

NM_004514
NM_181430
NM_181431

NM_001080932
NM_001363033

RefSeq (protein)

NP_004505

NP_001074401
NP_001349962

Location (UCSC)Chr 17: 82.52 – 82.64 MbChr 11: 121.26 – 121.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000141568 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039275 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR (Jul 1988). "Characterization of antigen receptor response elements within the interleukin-2 enhancer". Mol Cell Biol. 8 (4): 1715–24. doi:10.1128/MCB.8.4.1715. PMC 363332. PMID 3260003.
  6. "Entrez Gene: FOXK2 forkhead box K2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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