MEIS2

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.[5][6]

MEIS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K2A, 5BNG, 4XRM
Identifiers
Aliases	MEIS2, HsT18361, MRG1, Meis homeobox 2, CPCMR
External IDs	OMIM: 601740 MGI: 108564 HomoloGene: 7846 GeneCards: MEIS2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q14 Start 36,889,204 bp[1] End 37,101,299 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E4-E5|2 58.28 cM Start 115,863,064 bp[2] End 116,065,839 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001104 transcription coregulator activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • DNA binding Cellular component • cytoplasm • perinuclear region of cytoplasm • cell nucleus Biological process • eye development • visual learning • regulation of transcription, DNA-templated • response to mechanical stimulus • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • multicellular organism development • pancreas development • response to growth factor • negative regulation of myeloid cell differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mitotic cell cycle • positive regulation of cardiac muscle myoblast proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4212	17536
Ensembl	ENSG00000134138	ENSMUSG00000027210
UniProt	O14770	P97367
RefSeq (mRNA)	NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316	NM_001136072 NM_001159567 NM_001159568 NM_001159569 NM_001159570 NM_010825 NM_001346036 NM_001346038 NM_001346041 NM_001346044 NM_001346045 NM_001346047 NM_001346053 NM_001346055 NM_001346056
RefSeq (protein)	NP_001207411 NP_002390 NP_733774 NP_733775 NP_733776 NP_733777 NP_758526 NP_758527	NP_001129544 NP_001153039 NP_001153040 NP_001153041 NP_001153042 NP_001332965 NP_001332967 NP_001332970 NP_001332973 NP_001332974 NP_001332976 NP_001332982 NP_001332984 NP_001332985 NP_034955
Location (UCSC)	Chr 15: 36.89 – 37.1 Mb	Chr 2: 115.86 – 116.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.[6]