FOXF1

FOXF1
Identifiers
Aliases	FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1
External IDs	OMIM: 601089 MGI: 1347470 HomoloGene: 1114 GeneCards: FOXF1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	86,515,422 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	121,088,144 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• transcription regulator complex; • cell nucleus;
Biological process	• somitogenesis; • regulation of smooth muscle cell differentiation; • renal system development; • ureter development; • regulation of transcription, DNA-templated; • lung morphogenesis; • embryonic foregut morphogenesis; • lung development; • positive regulation of cell migration; • endocardial cushion development; • cellular response to organic cyclic compound; • extracellular matrix organization; • cardiac left ventricle morphogenesis; • in utero embryonic development; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of mast cell degranulation; • smooth muscle cell differentiation; • morphogenesis of a branching structure; • venous blood vessel development; • cellular response to cytokine stimulus; • right lung morphogenesis; • transcription, DNA-templated; • vasculogenesis; • positive regulation of transcription, DNA-templated; • respiratory tube development; • heart development; • determination of left/right symmetry; • establishment of epithelial cell apical/basal polarity; • blood vessel development; • embryonic ectodermal digestive tract morphogenesis; • positive regulation of mesenchymal cell proliferation; • embryonic digestive tract morphogenesis; • animal organ morphogenesis; • pancreas development; • detection of wounding; • mesenchyme migration; • smoothened signaling pathway; • lateral mesodermal cell differentiation; • lung alveolus development; • digestive tract development; • lung vasculature development; • mesoderm development; • epithelial tube branching involved in lung morphogenesis; • negative regulation of inflammatory response; • lung lobe morphogenesis; • ductus arteriosus closure; • embryonic digestive tract development; • positive regulation of transcription from RNA polymerase II promoter; • epithelial cell differentiation involved in mammary gland alveolus development; • midgut development; • positive regulation of cell-substrate adhesion; • transcription from RNA polymerase II promoter; • cell differentiation; • cell-cell adhesion; • trachea development;
	Sources:Amigo / QuickGO
Orthologs
	2294
	15227
	ENSG00000103241
	ENSMUSG00000042812
	Q12946
	Q61080
	NM_001451
	NM_010426
	NP_001442
	NP_034556
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.[5][6][7]

Function

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.[7]

References

GRCh38: Ensembl release 89: ENSG00000103241 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042812 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
"Entrez Gene: FOXF1 forkhead box F1".

External links

FOXF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103241 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042812 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8825632-5] Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.

[pmid7957066-6] Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.

[entrez-7] "Entrez Gene: FOXF1 forkhead box F1".

FOXF1

Function

References

Further reading

External links