STAT6

Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[5][6]

STAT6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
External IDsOMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.3Start57,095,408 bp[1]
End57,132,139 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6778

20852

Ensembl

ENSG00000166888

ENSMUSG00000002147

UniProt

P42226

P52633

RefSeq (mRNA)

NM_001178078
NM_001178079
NM_001178080
NM_001178081
NM_003153

NM_009284

RefSeq (protein)

NP_001171549
NP_001171550
NP_001171551
NP_001171552
NP_003144

NP_033310

Location (UCSC)Chr 12: 57.1 – 57.13 MbChr 10: 127.64 – 127.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[7]

Interactions

STAT6 has been shown to interact with:

Pathology

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000166888 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002147 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Leek JP, Hamlin PJ, Bell SM, Lench NJ (1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3–4): 208–9. doi:10.1159/000134723. PMID 9605853.
  6. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (Sep 1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science. 265 (5179): 1701–6. Bibcode:1994Sci...265.1701H. doi:10.1126/science.8085155. PMID 8085155.
  7. "Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced".
  8. McDonald C, Reich NC (Jul 1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". Journal of Interferon & Cytokine Research. 19 (7): 711–22. doi:10.1089/107999099313550. PMID 10454341.
  9. Litterst CM, Pfitzner E (Dec 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". The Journal of Biological Chemistry. 276 (49): 45713–21. doi:10.1074/jbc.M108132200. PMID 11574547.
  10. Gupta S, Jiang M, Anthony A, Pernis AB (Dec 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". The Journal of Experimental Medicine. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358.
  11. Shen CH, Stavnezer J (Jun 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Molecular and Cellular Biology. 18 (6): 3395–404. doi:10.1128/mcb.18.6.3395. PMC 108921. PMID 9584180.
  12. Litterst CM, Pfitzner E (Sep 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". The Journal of Biological Chemistry. 277 (39): 36052–60. doi:10.1074/jbc.M203556200. PMID 12138096.
  13. Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal. 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934.
  14. Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S (Jun 2005). "Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology. 23 (16): 3706–12. doi:10.1200/JCO.2005.00.232. PMID 15867200.
  15. Doyle LA, Tao D, Mariño-Enríquez A (Sep 2014). "STAT6 is amplified in a subset of dedifferentiated liposarcoma". Modern Pathology. 27 (9): 1231–7. doi:10.1038/modpathol.2013.247. PMID 24457460.

Further reading

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