MYB (gene)

Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper.[5][6] Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.

Myb-like DNA-binding domain
Identifiers
SymbolMyb_DNA-binding
PfamPF00249
InterProIPR001005
CATH1irz
SCOP21irz / SCOPe / SUPFAM
CDDcd00167
MYB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
External IDsOMIM: 189990 MGI: 97249 HomoloGene: 31311 GeneCards: MYB
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q23.3Start135,181,308 bp[1]
End135,219,173 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4602

17863

Ensembl

ENSG00000118513

ENSMUSG00000019982

UniProt

P10242
Q708E1

P06876

RefSeq (mRNA)

NM_001198914
NM_010848
NM_033597

RefSeq (protein)

NP_001185843
NP_034978

Location (UCSC)Chr 6: 135.18 – 135.22 MbChr 10: 21.12 – 21.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Viral

The Myb gene family is named after the eponymous gene in Avian myeloblastosis virus. The viral Myb (v-Myb, P01104) recognizes the sequence 5'-YAACKG-3'. It causes myeloblastosis (myeloid leukemia) in chickens.[7] Compared to the normal animal cellular Myb (c-myb), v-myb contains deletions in the C-terminal regulatory domain, leading to aberrant activation of other oncogenes.[8]

Animals

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. It may play a role in cell cycle regulation. Like the viral version, this gene is an oncogene, and rearrangements of the gene (often involving deletion in the C-terminal domain) causes cancer.[8]

Plants

MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.[9]

In maize, phlobaphenes are synthesized in the flavonoids synthetic pathway[10] from polymerisation of flavan-4-ols[11][12] which encodes an R2R3 myb-like transcriptional activator[13] of the A1 gene encoding for the dihydroflavonol 4-reductase (reducing dihydroflavonols into flavan-4-ols)[14] while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as a suppressor.[15] The maize P gene encodes a Myb homolog that recognizes the sequence CCWACC, in sharp contrast with the YAACGG bound by vertebrate Myb proteins.[16]

In sorghum, the corresponding yellow seed 1 gene (y1)[17] also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes required for the biosynthesis of 3-deoxyflavonoids.[18]

Ruby is a MYB transcriptional activator of genes that produce anthocyanin in citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.[19]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000118513 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019982 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.
  6. "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".
  7. Klempnauer KH, Symonds G, Evan GI, Bishop JM (June 1984). "Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene". Cell. 37 (2): 537–47. doi:10.1016/0092-8674(84)90384-2. PMID 6327074. S2CID 46196167.
  8. George OL, Ness SA (October 2014). "Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis". Cancers. 6 (4): 2049–71. doi:10.3390/cancers6042049. PMC 4276956. PMID 25279451.
  9. Stracke R, Werber M, Weisshaar B (October 2001). "The R2R3-MYB gene family in Arabidopsis thaliana". Curr. Opin. Plant Biol. 4 (5): 447–56. doi:10.1016/s1369-5266(00)00199-0. PMID 11597504.
  10. Himi E, Mares DJ, Yanagisawa A, Noda K (July 2002). "Effect of grain colour gene (R) on grain dormancy and sensitivity of the embryo to abscisic acid (ABA) in wheat". J. Exp. Bot. 53 (374): 1569–74. doi:10.1093/jxb/erf005. PMID 12096095.
  11. Winkel-Shirley B (June 2001). "Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiol. 126 (2): 485–93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179.
  12. Chopra S, Cocciolone SM, Bushman S, Sangar V, McMullen MD, Peterson T (March 2003). "The maize unstable factor for orange1 is a dominant epigenetic modifier of a tissue specifically silent allele of pericarp color1". Genetics. 163 (3): 1135–46. PMC 1462483. PMID 12663550.
  13. Structural And Transcriptional Analysis Of The Complex P1-wr Cluster In Maize. Wolfgang Goettel, Joachim Messing. Plant & Animal Genomes XVI Conference Archived 2012-02-18 at the Wayback Machine
  14. Dong X, Braun EL, Grotewold E (September 2001). "Functional conservation of plant secondary metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with maize genes" (PDF). Plant Physiol. 127 (1): 46–57. doi:10.1104/pp.127.1.46. PMC 117961. PMID 11553733.
  15. Lee EA, Harper V (2002). "Suppressor of Pericarp Pigmentation 1 (SPP1), a novel gene involved in phlobaphene accumulation in maize (Zea mays L.) pericarps". Maydica. 47 (1): 51–58. INIST:13772300
  16. Grotewold E, Drummond BJ, Bowen B, Peterson T (1994). "The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset". Cell. 76 (3): 543–554. doi:10.1016/0092-8674(94)90117-1. PMID 8313474. S2CID 42197232.
  17. Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S (2005). "Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids". Plant Science. 169 (3): 542–552. doi:10.1016/j.plantsci.2005.05.007. INIST:16983977
  18. Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S (January 2006). "Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis". Plant Mol. Biol. 60 (2): 185–99. doi:10.1007/s11103-005-3568-1. PMID 16429259. S2CID 23841582.
  19. Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C (2012). "Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges". Plant Cell. 24 (3): 1242–55. doi:10.1105/tpc.111.095232. PMC 3336134. PMID 22427337.

Further reading

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