HIVEP3

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.[5][6]

HIVEP3
Identifiers
AliasesHIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDsOMIM: 606649 MGI: 106589 HomoloGene: 7803 GeneCards: HIVEP3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p34.2Start41,506,365 bp[1]
End42,035,925 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

59269

16656

Ensembl

ENSG00000127124

ENSMUSG00000028634

UniProt

Q5T1R4

A2A884

RefSeq (mRNA)

NM_001127714
NM_024503

NM_010657

RefSeq (protein)

NP_001121186
NP_078779

NP_034787

Location (UCSC)Chr 1: 41.51 – 42.04 MbChr 4: 119.73 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]

It regulates osteoblasts.[7]

Interactions

HIVEP3 has been shown to interact with TRAF1[8] and TRAF2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000127124 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028634 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hicar MD, Liu Y, Allen CE, Wu LC (Jan 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics. 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801.
  6. "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
  7. Glimcher, LH; Jones, DC; Wein, MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3". Annals of the New York Academy of Sciences. 1116 (1): 174–81. Bibcode:2007NYASA1116..174G. doi:10.1196/annals.1402.044. PMID 18083927. S2CID 25260678.
  8. Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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