HOXA7

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[4][5][6]

HOXA7
Identifiers
AliasesHOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDsOMIM: 142950 MGI: 96179 HomoloGene: 56001 GeneCards: HOXA7
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p15.2Start27,153,716 bp[1]
End27,157,936 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3204

15404

Ensembl

ENSG00000122592

ENSMUSG00000038236

UniProt

P31268

P02830

RefSeq (mRNA)

NM_006896

NM_010455

RefSeq (protein)

NP_008827

NP_034585

Location (UCSC)Chr 7: 27.15 – 27.16 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000122592 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  5. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  6. "Entrez Gene: HOXA7 homeobox A7".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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