ING4

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[5][6]

ING4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesING4, my036, p29inhibitor of growth family member 4
External IDsOMIM: 608524 MGI: 107307 HomoloGene: 22952 GeneCards: ING4
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start6,650,301 bp[1]
End6,663,142 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51147

28019

Ensembl

ENSG00000111653

ENSMUSG00000030330

UniProt

Q9UNL4

Q8C0D7

RefSeq (mRNA)

NM_133345
NM_144510
NM_001368695

RefSeq (protein)

NP_579923
NP_001355624

Location (UCSC)Chr 12: 6.65 – 6.66 MbChr 6: 125.04 – 125.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[6]

Interactions

ING4 has been shown to interact with EP300,[5] RELA[7] and P53.[5][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000111653 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030330 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Research. 63 (10): 2373–8. PMID 12750254.
  6. "Entrez Gene: ING4 inhibitor of growth family, member 4".
  7. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK (March 2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature. 428 (6980): 328–32. Bibcode:2004Natur.428..328G. doi:10.1038/nature02329. PMID 15029197. S2CID 4427531.
  8. Tsai KW, Tseng HC, Lin WC (October 2008). "Two wobble-splicing events affect ING4 protein subnuclear localization and degradation". Experimental Cell Research. 314 (17): 3130–41. doi:10.1016/j.yexcr.2008.08.002. PMID 18775696.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.