MEOX1

MEOX1
Identifiers
Aliases	MEOX1, KFS2, MOX1, mesenchyme homeobox 1
External IDs	OMIM: 600147 MGI: 103220 HomoloGene: 3326 GeneCards: MEOX1
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	43,661,922 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	101,894,374 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • HMG box domain binding; • chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • core promoter sequence-specific DNA binding; • GO:0001948 protein binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • molecular function; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cytoplasm; • cell nucleus;
Biological process	• regulation of transcription, DNA-templated; • somite specification; • transcription from RNA polymerase II promoter; • sclerotome development; • transcription, DNA-templated; • multicellular organism development; • hematopoietic stem cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • somite development; • biological process;
	Sources:Amigo / QuickGO
Orthologs
	4222
	17285
	ENSG00000005102
	ENSMUSG00000001493
	P50221
	P32442
	NM_001040002; NM_004527; NM_013999
	NM_010791
	NP_001035091; NP_004518; NP_054705
	NP_034921
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.[5][6]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

Interactions

MEOX1 has been shown to interact with PAX1[7] and PAX3.[7]

References

GRCh38: Ensembl release 89: ENSG00000005102 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001493 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.
"Entrez Gene: MEOX1 mesenchyme homeobox 1".
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

Jones KA, Black DM, Brown MA, Griffiths BL, Nicolai HM, Chambers JA, Bonjardim M, Xu CF, Boyd M, McFarlane R (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase". Hum. Mol. Genet. 3 (11): 1927–34. doi:10.1093/hmg/3.11.1927. PMID 7874108.
Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin". Differentiation. 62 (1): 33–41. doi:10.1046/j.1432-0436.1997.6210033.x. PMID 9373945.
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells". J. Biol. Chem. 279 (23): 23874–81. doi:10.1074/jbc.M312612200. PMID 15039437.
Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells". J. Biol. Chem. 280 (22): 21022–8. doi:10.1074/jbc.M502977200. PMID 15793308.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005102 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001493 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7987315-5] Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.

[entrez-6] "Entrez Gene: MEOX1 mesenchyme homeobox 1".

[pmid11423130-7] Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

MEOX1

Function

Interactions

References

Further reading