HOXB1

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.[5][6][7]

HOXB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOXB1, HCFP3, HOX2, HOX2I, Hox-2.9, homeobox B1
External IDsOMIM: 142968 MGI: 96182 HomoloGene: 1615 GeneCards: HOXB1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start48,528,526 bp[1]
End48,531,011 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3211

15407

Ensembl

ENSG00000120094

ENSMUSG00000018973

UniProt

P14653

P17919

RefSeq (mRNA)

NM_002144

NM_008266

RefSeq (protein)

NP_002135

NP_032292

Location (UCSC)Chr 17: 48.53 – 48.53 MbChr 11: 96.37 – 96.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.[7]

Interactions

HOXB1 has been shown to interact with PBX1.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000120094 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018973 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. "Entrez Gene: HOXB1 homeobox B1".
  8. Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (March 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  9. Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (February 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. S2CID 16122785.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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