HOXD1

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.[5][6][7]

HOXD1
Identifiers
AliasesHOXD1, HOX4, HOX4G, Hox-4.7, homeobox D1
External IDsOMIM: 142987 MGI: 96201 HomoloGene: 7772 GeneCards: HOXD1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q31.1Start176,188,668 bp[1]
End176,190,907 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3231

15429

Ensembl

ENSG00000128645

ENSMUSG00000042448

UniProt

Q9GZZ0

Q01822

RefSeq (mRNA)

NM_024501

NM_010467

RefSeq (protein)

NP_078777

NP_034597

Location (UCSC)Chr 2: 176.19 – 176.19 MbChr 2: 74.76 – 74.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000128645 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042448 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. "Entrez Gene: HOXD1 homeobox D1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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