Germ cell nuclear factor

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.[5][6] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

NR6A1
Identifiers
Aliases	NR6A1, CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR, nuclear receptor subfamily 6 group A member 1
External IDs	OMIM: 602778 MGI: 1352459 HomoloGene: 36308 GeneCards: NR6A1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 124,517,275 bp[1] End 124,771,311 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 38,723,370 bp[2] End 38,927,688 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleoplasm • cell nucleus • transcription regulator complex Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • gamete generation • spermatogenesis • transcription initiation from RNA polymerase II promoter • cellular proliferation • positive regulation of transcription from RNA polymerase II promoter • intracellular steroid hormone receptor signaling pathway • intracellular receptor signaling pathway • steroid hormone mediated signaling pathway • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2649	14536
Ensembl	ENSG00000148200	ENSMUSG00000063972
UniProt	Q15406	Q64249
RefSeq (mRNA)	NM_001278546 NM_001489 NM_033334 NM_033335	NM_001159548 NM_001159549 NM_010264
RefSeq (protein)	NP_001265475 NP_001480 NP_201591 NP_201591.2	NP_001153020 NP_001153021 NP_034394
Location (UCSC)	Chr 9: 124.52 – 124.77 Mb	Chr 2: 38.72 – 38.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.[7]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.[8]