LYL1

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.[5][6]

LYL1
Identifiers
AliasesLYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDsOMIM: 151440 MGI: 96891 HomoloGene: 4078 GeneCards: LYL1
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.13Start13,099,033 bp[1]
End13,103,161 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4066

17095

Ensembl

ENSG00000104903

ENSMUSG00000034041

UniProt

P12980

P27792

RefSeq (mRNA)

NM_005583

NM_008535

RefSeq (protein)

NP_005574

NP_032561

Location (UCSC)Chr 19: 13.1 – 13.1 MbChr 8: 84.7 – 84.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

LYL1 has been shown to interact with TCF3[7] and NFKB1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000104903 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034041 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.
  6. "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
  7. Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
  8. Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

Further reading

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