CNBP

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.[5][6][7]

CNBP
Identifiers
AliasesCNBP, CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9, CCHC-type zinc finger nucleic acid binding protein
External IDsOMIM: 116955 MGI: 88431 HomoloGene: 2567 GeneCards: CNBP
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q21.3Start129,169,484 bp[1]
End129,183,922 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7555

12785

Ensembl

ENSG00000169714

ENSMUSG00000030057

UniProt

P62633

P53996

RefSeq (mRNA)

NM_001109745
NM_001109746
NM_013493
NM_001347325
NM_001355195

RefSeq (protein)

NP_001103215
NP_001103216
NP_001334254
NP_038521
NP_001342124

Location (UCSC)Chr 3: 129.17 – 129.18 MbChr 6: 87.84 – 87.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000169714 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030057 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS (Oct 1990). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics. 8 (2): 411–4. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
  6. Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP (Aug 2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science. 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088. S2CID 30903810.
  7. "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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