Estrogen-related receptor beta

ESRRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LO1
Identifiers
Aliases	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2
External IDs	OMIM: 602167 MGI: 1346832 HomoloGene: 69108 GeneCards: ESRRB
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	76,501,837 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	86,521,628 bp[2]
Gene ontology
Molecular function	• steroid binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • zinc ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • transcription factor binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001105 transcription coactivator activity; • GO:0001948 protein binding; • RNA polymerase II core binding; • GO:0001158 core promoter proximal region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;
Cellular component	• cell nucleus; • nucleoplasm; • condensed chromosome; • integrator complex; • chromosome; • cytoplasm;
Biological process	• regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • embryonic placenta development; • transcription, DNA-templated; • steroid hormone mediated signaling pathway; • transcription initiation from RNA polymerase II promoter; • intracellular receptor signaling pathway; • stem cell population maintenance; • negative regulation of transcription from RNA polymerase II promoter; • cellular proliferation; • stem cell division; • cell dedifferentiation; • photoreceptor cell maintenance; • positive regulation of transcription, DNA-templated; • inner ear development; • positive regulation of transcription involved in G1/S transition of mitotic cell cycle; • positive regulation of transcription involved in G2/M transition of mitotic cell cycle; • positive regulation of stem cell population maintenance; • regulation of stem cell division; • negative regulation of stem cell differentiation; • positive regulation of glycogen biosynthetic process; • positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	2103
	26380
	ENSG00000119715
	ENSMUSG00000021255
	O95718
	Q61539
	NM_004452; NM_001379180
	NM_001159500; NM_011934
	NP_004443; NP_001366109
	NP_001152972; NP_036064
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[5]

Function

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[5]

References

GRCh38: Ensembl release 89: ENSG00000119715 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021255 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ESRRB estrogen-related receptor beta".

Giguère V, Yang N, Segui P, Evans RM (Jan 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (Oct 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655.
Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA (Dec 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750.
Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (Dec 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588.
Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (Apr 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–32. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265.
Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (Nov 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452. S2CID 86143014.
Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (Jul 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914.
Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (Aug 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259.
Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE (Aug 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907.
Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (Feb 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156.
Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL (Mar 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.
Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (Feb 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119715 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021255 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ESRRB estrogen-related receptor beta".

Estrogen-related receptor modulators
ERRα	Agonists: 6,3′,4′-Trihydroxyflavone Biochanin A Bisphenol AF Cholesterol Daidzein Genistein Antagonists: Diethylstilbestrol XCT-790
ERRβ	Agonists: DY-131 (GSK-9089) GSK-4716 (GW-4716) Antagonists: 4-Hydroxytamoxifen (afimoxifene) Bisphenol AF Diethylstilbestrol
ERRγ	Agonists: Bisphenol A DY-131 (GSK-9089) GSK-4716 (GW-4716) Antagonists: 4-Hydroxytamoxifen (afimoxifene) Diethylstilbestrol
See also Receptor/signaling modulators

Estrogen-related receptor beta

Function

References

Further reading