CBX3

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.[5][6]

CBX3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
External IDsOMIM: 604477 MGI: 108515 HomoloGene: 40583 GeneCards: CBX3
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p15.2Start26,201,162 bp[1]
End26,213,607 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11335

12417

Ensembl

ENSG00000122565

ENSMUSG00000029836

UniProt

Q13185

P23198

RefSeq (mRNA)

NM_007276
NM_016587

NM_001037798
NM_007624
NM_001355002

RefSeq (protein)

NP_009207
NP_057671

n/a

Location (UCSC)Chr 7: 26.2 – 26.21 MbChr 6: 51.47 – 51.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[6]

Interactions

CBX3 has been shown to interact with PIM1,[7] Ki-67,[8] Lamin B receptor,[9] CBX5[10] and CBX1.[10]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000122565 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029836 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
  6. "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
  7. Koike, N; Maita H; Taira T; Ariga H; Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi:10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. S2CID 29392124.
  8. Kametaka, Ai; Takagi Masatoshi; Hayakawa Tomohiro; Haraguchi Tokuko; Hiraoka Yasushi; Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. S2CID 6802841.
  9. Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349.
  10. Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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