CooA

CooA is a heme-containing transcription factor that responds to the presence of carbon monoxide. This protein is a homolog of cyclic AMP receptor protein and forms homodimers.[1] It induces the expression of carbon monoxide dehydrogenase, which oxidizes CO. In the inactive ferric state, iron is bound to cysteine thiolate and the amine of an N-terminal proline, in addition to the N4 donor set of the porphyrinate. In the reduced state, an imidazole of histidine displaces the thiolate. The midpoint potential is -300 mV. In the presence of CO, the secondary amine ligand provided by proline is displaced from Fe. It is this CO-bound form that interacts with DNA.[2][3]

References
  1. H. Körner; H. J. Sofia; W. G. Zumft (2003). "Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs". FEMS Microbiology Reviews. 27 (5): 559–592. doi:10.1016/S0168-6445(03)00066-4. PMID 14638413.
  2. G. P. Roberts; R. L. Kerby; H. Youn; M. Conrad (2005). "CooA, A Paradigm for Gas Sensing Regulatory Proteins". J. Inorg. Biochem. 99 (1): 280–92. doi:10.1016/j.jinorgbio.2004.10.032. PMID 15598507.
  3. Shigetoshi Aono (2003). "Biochemical and Biophysical Properties of the CO-Sensing Transcriptional Activator CooA". Acc. Chem. Res. 36 (11): 825–31. doi:10.1021/ar020097p. PMID 14622029.
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