PEG3

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[5][6] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[8]

PEG3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPEG3, PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDsOMIM: 601483 MGI: 104748 HomoloGene: 31363 GeneCards: PEG3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.43Start56,810,077 bp[1]
End56,840,728 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5178

18616

Ensembl

ENSG00000198300

ENSMUSG00000002265

UniProt

Q9GZU2

Q3URU2

RefSeq (mRNA)

NM_006210
NM_001146184
NM_001146185
NM_001146186
NM_001146187

NM_008817

RefSeq (protein)

NP_001139656
NP_001139657
NP_001139658
NP_001139659
NP_006201

NP_032843

Location (UCSC)Chr 19: 56.81 – 56.84 MbChr 7: 6.7 – 6.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

PEG3 has been shown to interact with SIAH2[9] and SIAH1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000198300 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002265 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
  6. "Entrez Gene: PEG3 paternally expressed 3".
  7. Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12): e83359. doi:10.1371/journal.pone.0083359. PMC 3877027. PMID 24391757.
  8. Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
  9. Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.

Further reading



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