GTF2A1

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.[5][6]

GTF2A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGTF2A1, TF2A1, TFIIA, TFIIA-42, TFIIAL, general transcription factor IIA subunit 1
External IDsOMIM: 600520 MGI: 1933277 HomoloGene: 56331 GeneCards: GTF2A1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q31.1Start81,175,452 bp[1]
End81,221,377 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2957

83602

Ensembl

ENSG00000165417

ENSMUSG00000020962

UniProt

P52655

Q99PM3

RefSeq (mRNA)

NM_201595
NM_001278940
NM_015859

NM_031391
NM_175335

RefSeq (protein)

NP_001265869
NP_056943
NP_963889

NP_113568
NP_780544

Location (UCSC)Chr 14: 81.18 – 81.22 MbChr 12: 91.56 – 91.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

GTF2A1 has been shown to interact with TATA binding protein[7][8][9][10][11] and TBPL1.[12][13]

See also

Model organisms

Model organisms have been used in the study of GTF2A1 function. A conditional knockout mouse line called Gtf2a1tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[14] Male and female animals underwent a standardized phenotypic screen[15] to determine the effects of deletion.[16][17][18][19] Additional screens performed: - In-depth immunological phenotyping[20]

References
  1. GRCh38: Ensembl release 89: ENSG00000165417 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020962 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. DeJong J, Roeder RG (Nov 1993). "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA". Genes & Development. 7 (11): 2220–34. doi:10.1101/gad.7.11.2220. PMID 8224848.
  6. "Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa".
  7. DeJong J, Bernstein R, Roeder RG (Apr 1995). "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3313–7. Bibcode:1995PNAS...92.3313D. doi:10.1073/pnas.92.8.3313. PMC 42156. PMID 7724559.
  8. Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B (Oct 2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". The Journal of Biological Chemistry. 276 (42): 38652–7. doi:10.1074/jbc.M106422200. PMC 4492724. PMID 11509574.
  9. Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM (Jun 1998). "Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding". The Journal of Biological Chemistry. 273 (23): 14293–300. doi:10.1074/jbc.273.23.14293. PMID 9603936.
  10. Solow S, Salunek M, Ryan R, Lieberman PM (May 2001). "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity". The Journal of Biological Chemistry. 276 (19): 15886–92. doi:10.1074/jbc.M009385200. PMID 11278496.
  11. Sun X, Ma D, Sheldon M, Yeung K, Reinberg D (Oct 1994). "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription". Genes & Development. 8 (19): 2336–48. doi:10.1101/gad.8.19.2336. PMID 7958900.
  12. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  13. Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. Bibcode:1999PNAS...9613720T. doi:10.1073/pnas.96.24.13720. PMC 24131. PMID 10570139.
  14. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  15. "International Mouse Phenotyping Consortium".
  16. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  19. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  20. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading
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