Outline of immunology

The following outline is provided as an overview of and topical guide to immunology:

Immunology is the study of all aspects of the immune system in all organisms.[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Essence of immunology


Immunology

Branches of immunology

History of immunology

History of immunology

General immunological concepts

  • Immunity against:

Components of the immune system

Immune system

  Adaptive immune system

Adaptive immune system

  • Kinds of antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system

Innate immune system

  • Positive
  • Negative

Organs of the immune system

Lymphatic system

  Primary lymphoid organs

Primary lymphoid organs

  Secondary lymphoid organs

Secondary lymphoid organs

Cells of the immune system

White blood cells

  Myeloid cells

  • Dendritic Cells

  Lymphoid cells

Lymphoid cells

  Others

(Non-hematopoietic cells with immune functions)

  Hematopoiesis

  • T cell development
  • B cell development
  • Pre-pro-B cell
  • Early pro-B cell
  • Late pro-B cell
  • Large pre-B cell
  • Small pre-B cell
  • Immature B cell
  • Mast cell precursors

Molecules of the immune system

Immune receptors

   Antigen receptors

  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs)

Pattern recognition receptor

  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • MSR1 (SCARA1)
  • MARCO (SCARA2)
  • SCARA3
  • SCARA4 (COLEC12)
  • SCARA5
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX
  • Secreted PRRs

   Complement receptors

Complement receptor

   Fc receptors

Fc receptor

  • Secreted Fc receptors

   Cytokine receptors

Cytokine receptor

  • IL2R - Heterotrimer: IL2RA (CD25) / IL2RB (CD122) / γc
  • IL4R / IL13R - Heterodimer: IL4RA / (IL13RA1/IL13RA2)
  • IL7R - Heterodimer: IL7RA (CD127) / γ-chain
  • IL9R - Heterodimer: IL9R / γ-chain
  • IL15R - Heterotrimer: IL15RA / IL2RB / γ-chain
  • IL21R - Heterodimer: IL21R / γ-chain
  • Common beta chain (β-chain, CD131)
  • IL6R - Heterodimer: IL6RA / gp130
  • IL11R - Heterodimer: IL11RA / gp130
  • IL27R - Heterodimer: IL27RA / gp130
  • OSMR - Heterodimer: OSMR / gp130
  • LIFR (CD118) - Heterodimer: LIFR / gp130
  • IL12 receptor beta 1 subunit (IL12RB1)
  • IL12R - Heterodimer: IL12RB1 / IL12RB2
  • IL23R - Heterodimer: IL23RA / IL12RB1
  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors
  • IL10R - Heterodimer: IL10RA / IL10RB
  • IL20R - Heterodimer: IL20RA / IL20RB
  • IL22R - Heterodimer: IL22RA1 / IL10RB
  • IL28R - Heterodimer: IL28RA / IL10RB
  • CSF1
  • CD117 (c-KIT)
  • IL1 receptor family (IL1R)
  • IL17 family
  • C chemokine receptors (XCRs)
  • CX3C chemokine receptors (CX3CRs)

   Natural killer cell receptors

Natural killer cell receptors

  • Natural cytotoxicity receptors (NCRs)
  • Natural killer group 2 receptors (NKG2s)
  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail
  • KIR3DS1

   Others

  • LILR subfamily A
  • LILR subfamily B

Antibodies

Antibodies

Cytokines

Cytokine

  • CX3CL1 (Fractalkine, Neurotactin)

MHCs

Major histocompatibility complex

Complement proteins

  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides

Antimicrobial peptides

Transcription factors

  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways

Cell adhesion molecules (CAMs)

Cell adhesion molecules

  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • CTX family
  • CD2 family
  • Others

Others

  • Co-stimulatory molecules
  • CD80 - Expressed by APCs
  • CD86 - Expressed by APCs
  • CD28 family receptors
  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders

Immune disorder

Hypersensitivity and Allergy

  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Transfusion-associated graft versus host disease
  • Unknown/Multiple types
  • Foreign
  • Autoimmune

Immunodeficiency

Immunodeficiency

Cancers of the immune system

Myeloid diseases

Inflammatory diseases

Immunoproliferative immunoglobulin disorders

Immunoproliferative immunoglobulin disorders

Lymphatic organ disease

Immunologic techniques and tests

Immunology and health

Immunologists

List of immunologists

Immunology lists

References

  1. Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  2. "HGNC Gene Group: C-type lectin domain containing". Retrieved 2019-08-30.
  3. Geijtenbeek TB, Gringhuis SI (July 2009). "Signalling through C-type lectin receptors: shaping immune responses". Nat. Rev. Immunol. 9 (7): 465–79. doi:10.1038/nri2569. PMC 7097056. PMID 19521399.
  4. Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome and inflammation". Nat. Rev. Immunol. 11 (12): 837–51. doi:10.1038/nri3089. PMID 22076558. S2CID 5266193.
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