PROX1

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.[5][6]

PROX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPROX1, prospero homeobox 1
External IDsOMIM: 601546 MGI: 97772 HomoloGene: 2069 GeneCards: PROX1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.3Start213,983,181 bp[1]
End214,041,510 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5629

19130

Ensembl

ENSG00000117707

ENSMUSG00000010175

UniProt

Q92786

P48437

RefSeq (mRNA)

NM_001270616
NM_002763

NM_008937
NM_001360827

RefSeq (protein)

NP_001257545
NP_002754

NP_032963
NP_001347756

Location (UCSC)Chr 1: 213.98 – 214.04 MbChr 1: 190.12 – 190.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PROX1 has been shown to interact with EP300.[7]

Production

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

Homologous gene

PROX2

References

  1. GRCh38: Ensembl release 89: ENSG00000117707 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000010175 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
  6. "Entrez Gene: PROX1 prospero-related homeobox 1".
  7. Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. United States. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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