βk-2C-B

βk-2C-B (beta-keto 2C-B, bk-2C-B) is a psychedelic drug which is structurally related to 2C-B and BOB[1] and has been sold online as a designer drug.[2] It was found to be a polymorph and is prone to selfcondensation forming a dimer under basic to neutral conditions, similar to the reaction involved in pyrazine synthesis.[3]

Βk-2C-B
Clinical data
Routes of
administration
Oral
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC10H12BrNO3
Molar mass274.111 g/mol (freebase)
310.572 g/mol (HCl salt) g·mol−1
3D model (JSmol)

Analogues and derivatives

Analogues and derivatives of 2C-B:

25-N:

  • 25B-N1POMe
  • 25B-NAcPip

25-NB:

25-NM:

  • 25B-NMe7BF
  • 25B-NMe7BT
  • 25B-NMe7Box
  • 25B-NMe7DHBF
  • 25B-NMe7Ind
  • 25B-NMe7Indz
  • 25B-NMePyr

Substituted benzofurans:

Other:

Canada

As of 12 October 2016, βk-2C-B became a controlled substance (Schedule III) in Canada.[4]

Europe

βk-2C-B is illegal in Switzerland,[5] Sweden[6] and the United Kingdom[7]

See also

References

  1. Glennon RA, Bondarev ML, Khorana N, Young R, May JA, Hellberg MR, et al. (November 2004). "Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane". Journal of Medicinal Chemistry. 47 (24): 6034–41. doi:10.1021/jm040082s. PMID 15537358.
  2. Frison G, Odoardi S, Frasson S, Sciarrone R, Ortar G, Romolo FS, Strano Rossi S (July 2015). "Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance". Rapid Communications in Mass Spectrometry. 29 (13): 1196–204. doi:10.1002/rcm.7211. PMID 26395784.
  3. Power JD, Kavanagh P, O'Brien J, Barry M, Twamley B, Talbot B, et al. (June 2015). "Test purchase, identification and synthesis of 2-amino-1-(4-bromo-2, 5-dimethoxyphenyl)ethan-1-one (bk-2C-B)". Drug Testing and Analysis. 7 (6): 512–8. doi:10.1002/dta.1699. PMID 25078895.
  4. "Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)". Controlled Substances Act. 2016-05-04.
  5. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.
  6. "Nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 18 August 2015.
  7. "Psychoactive Substances Act 2016". Home Office. Retrieved 8 September 2016.
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